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Job title
Consultant cardiologist;clinical service lead, cardiology;associate professor, UCL
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Biography
Dr Lockie attended University College School, before training at Edinburgh University. He undertook an intercalated degree, gaining first class honours. After graduation, he worked in Edinburgh before moving to London for his specialist cardiology training.
With an interest in ischaemic heart disease, he undertook a PhD at King’s College, London, winning the Young Investigator prize, as well as presenting and publishing his work around the world.
He spent a year at the Academic Medical Centre in Amsterdam undertaking further training in advanced percutaneous coronary interventions (PCI). He now works as a consultant interventional cardiologist at the Royal Free London.
Dr Lockie specialises in complex PCI, intravascular imaging and coronary physiology, and has an ongoing interest in research being the principle site investigator for several large studies.
He was appointed as clinical service lead for cardiology across all Royal Free London sites and associate professor of cardiology, Univeristy College London. He has also been elected as a fellow of the European Society of Cardiology.
Languages
English
GMC number
4604408
• M. Cristina Rolandi, Tim Lockie, Bart-Jan Verhoeff, Kalpa De Silva, Rupert Williams, Kaleab N. Asrress, Divaka Perera, Simon Redwood, Mike Marber, Jan Piek, Jos A.E. Spaan, Maria Siebes. Distinct responses of coronary forward and backward waves to tachycardia induced by pacing or exercise in patients with coronary artery disease. [submitted]
• Asrress KN, Williams R, Chiribiri A, Lockie T, Zeeshan Khawaja M, Guilcher A, Sammut E, Wesolowski R, De Silva K, Lumley M, Ihsan S, Patterson T, Ellis H, Chowienczyck PJ, Nagel E, Perera D, Plein S, Marber MS, Redwood SR. A Unravelling the mechanisms of exercise induced ischaemia, its optimal assessment, and alleviation with nitroglycerine. Heart. 2014 Jun;100 Suppl 3:A124-5. doi: 10.1136/heartjnl-2014-306118.229.
• M. C. Rolandi, K. De Silva, M. Lumley, T. Lockie, B Clapp, J. Spaan, D. Perera, M. Siebes. Wave speed in human coronary arteries is not influenced by microvascular vasodilation: implications for wave intensity analysis. Basic Res Cardiol. 2014 Mar;109(2):405.
• T. Lockie. What Can We Learn from the ESC 2013? Cardiology News. Jan 2014. Vol 17; 2; 6-11.
• Nolte F, van de Hoef TP, de Klerk W, Baan J Jr, Lockie T, Spaan JA, Piek JJ, Siebes M. Functional coronary stenosis severity assessed from the mean pressure gradient-velocity relationship obtained by contrast medium-induced submaximal hyperaemia. EuroIntervention. 2014 Jul;10(3):320-8
• T. Lockie. Structured Answer Questions in Cardiology (Royal College of Physicians). Clin Med. December 1, 2013 vol. 13 no. 6 621-622
• Tarkin JM, Nijjer S, Sen S, Petraco R, Echavarria-Pinto M, Asress KN, Lockie T, Khawaja MZ, Mayet J, Hughes AD, Malik IS, Mikhail GW, Baker CS, Foale RA, Redwood S, Francis DP, Escaned J, Davies JE. Hemodynamic Response to Intravenous Adenosine and Its Effect on Fractional Flow Reserve Assessment: Results of the Adenosine for the Functional Evaluation of Coronary Stenosis Severity (AFFECTS) Study. Circ Cardiovasc Interv. 2013 Dec 1;6(6):654-61
• T. Lockie, M. Cristina Rolandi, J.J Piek. Dynamic Damping Of The Aortic Pressure Trace During Hyperaemia: The Impact On Fractional Flow Reserve Measurement. J Invasive Cardiol. 2013 Oct;25(10):549-50.
• A Chiribiri, G Hautvast, T Lockie, A Schuster, B Bigalke, L Olivotti, S Redwood, M Breeuwer, S Plein, E Nagel. Quantitative analysis of transmural perfusion gradients by high-resolution magnetic resonance versus fractional flow reserve for the assessment of coronary artery stenosis severity and location. JACC Cardiovasc Imaging. 2013 May;6(5):600-9
• Tim Lockie, Simon Redwood. Future Directions for Percutaneous Mechanical Circulatory Support Devices. Interventional Cardiology Clinics 2013 vol. 2 (3) pp. 485-494
• Kalpa De Silva, Paul Foster, Antoine Guilcher, Asela Bandara, Roy Jogiya, Tim Lockie, Phil Chowiencyzk, Eike Nagel, Michael Marber, Simon Redwood, Sven Plein, Divaka Perera. Coronary Wave Energy: A Novel Predictor of Functional Recovery After Myocardial Infarction. Circ Cardiovasc Interv. 2013 Apr 1;6(2):166-75
• Johnson NP, Kirkeeide RL, Asrress KN, Fearon WF, Lockie T, Marques KM, Pyxaras S, Rolandi MC, van T Veer M, De Bruyne B, Piek JJ, Pijls NH, Redwood S, Siebes M, Spaan JA, Gould KL. Does the Instantaneous Wave-Free Ratio Approximate the Fractional Flow Reserve? J Am Coll Cardiol. 2013 Apr 2;61(13):1428-35
• T.P.E Lockie, M.C Rolandi, A. Guilcher, D. Perera, K. De Silva, R. Williams, K.N. Asrress, K. Patel, S. Plein, P. Chowienczyk, M. Siebes, S.R Redwood, M.S Marber. Synergistic Adaptations to Exercise in the Systemic and Coronary Circulations that Underlie the Warm-Up Angina Phenomenon. Circulation 2012 Nov 27;126(22):2565-74
• K. de Silva, P. Sicard, I. Webb, T. Lockie, S.Redwood, D.Perera. Does left ventricular function continue to influence mortality following contemporary percutaneous coronary intervention? Coron Artery Dis. 2012 May;23(3):155-61.
• M Motwani, T Lockie, JP Greenwood, S Plein. Accelerated, high spatial resolution cardiovascular magnetic resonance myocardial perfusion imaging. J Nucl Cardiol. 2011 Oct;18(5):952-8.
• G Hautvast, A Chiribiri, T Lockie, M Breeuwer, E Nagel, S Plein. Quantitative Analysis of Transmural Gradients in Perfusion CMR Images. Magn Reson Med. 2011 Nov;66(5):1477-87
• T Lockie, M Ishiwa, D Perera, K de Silva, S Kozerke, M Marber, E Nagel, S Redwood, S Plein. High-resolution magnetic resonance myocardial perfusion imaging at 3 tesla to detect haemodynamically significant coronary stenoses as determined by fractional flow reserve. J. of American College of Cardiology 2010 vol. 57 (1) pp. 70-5
• T Lockie, D Perera, K de Silva, I Webb, S Redwood. The Impact of Measuring Fractional Flow Reserve on Decision Making in the Cath Lab in an Unselected Cohort of Patients Being Considered for Coronary Revascularisation. J Invasive Cardiol. 2010 Sep;22 (9):413-6
• A Mather T Lockie, E Nagel, M Marber, D Perera, S Redwood, A Radjenovic, A Saha, J Greenwood, Sven Plein. Appearance of microvascular obstruction on high-resolution first-pass perfusion, early and late gadolinium enhancement CMR in patients with acute myocardial infarction. J of Cardiovascular Magnetic Resonance 2009, 11:33-37
• Lockie, T, Nagel, E, Redwood, S, Plein, S. The Use of Cardiovascular Magnetic Resonance Imaging in Acute Coronary Syndromes. Circulation 2009;119; 1671-1681
• Blume, U, Lockie T, Stehning C, Sinclair, S, Uribe, S, Razavi, R, Schaeffter T Interleaved T1- and T2-mapping method for cardiac applications. J. Magn. Reson. Imaging 2009; 29; 480-487
• Lockie T, Redwood S. Coronary Angiography: A Practical Guide for Trainees. Coronary Heart, Feb 2009
• Lockie T, Plein S, Redwood S. Microvascular Obstruction Following Primary Angioplasty: Beyond the Epicardial Artery. Heart Metab. 2008;40:26-29
• Lockie, T, Guram, A, Hildick-Smith, D. An unusual complication following transvenous pacing. Circulation. 2007 Apr 10;115(14):e386-7
• Lockie, T, Harrington, D. An unusual case of Atrioventricular heart block in a young vegan. Int J Cardiol. 2007 Mar 27; 88: 112-3
• Thomas A, Hayes P, Lockie T, Harrington D. Venflons: why do we insist on putting them in. Journal of Hospital Infection. 2006:18; 221-6
BOOK CHAPTERS
• T. Lockie, S. Redwood. Chapter 9. Future Directions for Percutaneous Mechanical Circulatory Support Devices. Elsevier Interventional Cardiology Clinics, Volume 2, Issue 3 , Pages 485-494, July 2013 (Editors Cohen & Henriques)
• T.Lockie, S. Redwood. Current use of Glycoprotein IIb/IIIa receptor Inhibitors. Chapter 23 pp 395-416. Oxford Textbook of Interventional Cardiology, Oxford University Press, 2010 [ISBN 978-0-19-956908-3]
Dr Lockie's research interests include:
• ischaemic heart disease
• intracoronary physiology
• cardiogenic shock
• acute coronary syndromes