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Job title
Consultant oncoplastic breast surgeon
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Biography
Mr Tan graduated with MBBS and MSc degrees from Imperial College London in 1995, and was in the basic surgical training programmes in Cambridge and London, leading to a MRCS Diploma.
He was then awarded with the MRC (UK) fellowship researching into genetic manipulation of immune and vascular cells, of which culminated in PhD and MD degrees with University of London.
He has been awarded with multiple awards by many learning societies and the Royal College of Surgeons. His work was recognised by the British Transplantation Society and the International Transplantation Society with an award of the Roy Calne Young Investigators Award and the New Key Opinion Leader of Tomorrow Award.
The Royal of Surgeons also recognised his contribution with an award of Syme Medal. In addition, he has won multiple travelling awards with the British Immunology Society and Pfizers Academy.
Mr Tan then went to Oxford University to become its lecturer in surgery and completed his higher surgical training programmes with the Oxford School of Surgery. From Oxford, he went onto further sub-speciality training in oncoplastic surgery at the Royal Marsden Foundation Trust and the Imperial College Healthcare NHS Trust.
He then completed his general surgery and oncoplastic breast training, leading to his fellowship with the Royal College of Surgeons.
Languages
English
GMC number
4258223
• Evolving role of adiponectin in cancer – controversies and update (Review Article)A Katira, PH Tan (Senior Authorship) Cancer Biology and Medicine 2016 Mar;13(1):101-19. doi: 10.28092/j.issn.2095-3941.2015.0092.
• Adiponectin and its receptor signaling: an anti-cancer therapeutic target and its implications for anti-tumor immunity (Review Article) A Katira, PH Tan (Senior Authorship) Expert Opinion Therapeutic Targets May 2015 19(8):1105-25
• Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity (Original Research Article) PH Tan, HE Tyrrell, L Gao, D Xu, J Quan, D Gill, L Rai, Y Ding, G Plant, Y Chen, JZ Xue, AI Handa, M Greenall, K Walsh, SA Xue Canncer Res 2014 Sept; 74(20): 1-12
• Mesenchymal stem cells differentially mediate regulatory T cells and conventional effector T cells to protect fully allogeneic islet grafts in mice (Original Research Article) DM Xu, XF Yu, D Zhang, MX Zhang, JF Zhou, PH Tan, YC Ding Diabetologia 2012 Apr; 55(4):1091-102
• Vascular endothelial growth factor receptors and cancer therapeutic targeting: where do we go from here? (Review Article) D Bruce, PH Tan (Senior Authorship) Cell Communication & Adhesion 2011 Oct; 18(5): 85-103
• Controlling the cost of breast cancer (Review Article) D Gill, D Bruce, PH Tan (Senior Authorship) Eur J Cancer Care (Engl) 2011 Nov; 20(6): 703-7
• Blocking the interaction of vascular endothelial growth factor receptors with their ligands and their effector signaling as a novel therapeutic target for cancer: time for a new look? (Review Article) D Bruce, PH Tan (Senior Authorship) Expert Opinion on Investigational Drugs 2011 Oct; 20(10): 1413-34
• Induction of pathogenic cytotoxic T lymphocyte tolerance by dendritic cells: a novel therapeutic target (Review Article) D Gill, PH Tan (Senior Authorship) Expert Opinion on Therapeutic Target 2010 Aug; 14(8): 797-824
• Manipulation of indoleamine 2, 3-dioxygenase (IDO); a novel therapeutic target for treatment of diseases (Review Article) PH Tan, AK Bharath Expert Opinion on Therapeutic Target 2009 Aug; 13(8): 987-1012
• Targeting gene delivery to activated vascular endothelium using anti-E/P selectin antibody linked to PAMAM dendrimers (Original Research Article) S Theoharis, U Krueger, PH Tan, DO Haskard, M Weber, AJ George Journal of Immunological Methods 2009 Apr 15; 343(2): 79-90
• Manipulation of indoleamine 2, 3-dioxygenase (IDO) for clinical transplantation; promises and challenges (Review Article) J Quan*, PH Tan* (*Joint First), A MacDonald, PJ Friend Expert Opinion on Biological Therapy 2008 Nov; 8(11): 1705-19
• Interaction of current cancer treatments and the immune system: implications for breast cancer therapeutics (Review Article) PH Tan, AS Lota Expert Opinion on Pharmacotherapy 2008 Oct; 9(15): 2639-60
• More trouble ahead; is gene therapy coming of age? (Review Article) PH Tan, SE Janes, AI Handa, PJ Friend Expert Opinion on Biological Therapy 2008 May; 8(5): 1-7
• Modulation of the immune response by targeting endothelial cells (Review Article) M Manunta, PH Tan, AJ George Current Medicinal Chemistry – Anti-Inflammatory & Anti-Allergy Agents 2007 May; 6(2): 171-181
• Gene delivery to vascular endothelium using chemical vectors; implications for cardiovascular gene therapy (Review Article) S Theoharis, M Manunta, PH Tan (Senior Authorship) Expert Opinion on Biological Therapy 2007 May; 7(5): 627-43
• Changing viral tropism using immunoliposomes alters the stability of gene expression: implications for viral vector design (Original Research Article) PH Tan*, SA Xue* (*Joint first), B Wei, A Holler, RH Voss, AJ George Molecular Medicine 2007 Mar-Apr; 13(3-4): 216-26
• Knockdown of mouse VCAM-1 by vector-based siRNA (Original Research Article) AK Alam, O Florey, M Weber, RG Pillai, C Chan, PH Tan, RI Lechler, MO McClure, DO Haskard, AJ George Transplant Immunology 2006 Nov; 16(3-4): 185-93
• Aspirin-treated human dendritic cells upregulate ILT-3 and induce hypo-responsiveness and regulatory activity in responder T cells (Original Research Article) M Buckland, CB Jago, H Fazekasova, K Scott, PH Tan, AJ George, R Lechler, G Lombardi American Journal of Transplantation 2006 Sep; 6(9): 2046-59
• Gene therapy for clinical transplantation; where do we stand in 2006? (Review Article) PH Tan, AJ George, AI Handa Discovery Medicine 2006 Aug; 6(34): 153-56
• Gene therapy for transplantation with viral vectors- how much of the promise has been realized? (Review Article) PH Tan, PL Tan, AJ George, CLH Chan Expert Opinion on Biological Therapy 2006 Aug; 6(8): 759-72
• Gene delivery by dendrimers operates via different pathways in different cells, but is enhanced by the presence of caveolin (Original Research Article) M Manunta, B Nichols, PH Tan, P Sagoo, JE Harper, AJ George Journal of Immunological Methods 2006 Jul; 314(1-2): 134-46
• Strategies to improve non-viral vectors- potential applications in clinical transplantation (Review Article) PH Tan, CLH Chan, AJ George Expert Opinion on Biological Therapy 2006 Jun; 6(6): 619-30
• Expression of indoleamine 2, 3-dioxygenase (IDO) on endothelial cells: implications for control of alloresponses (Original Research Article) SC Beutelspacher*, PH Tan*(*Joint First), MO McClure, DF Larkin, RI Lechler, AJ George American Journal of Transplantation 2006 Jun; 6(6): 1320-30
• Fat necrosis of the breast- a review (Review Article) PH Tan, LM Lai, EV Carrington, AS Opaluwa, KH Ravikumar, N Chetty, V Kaplan, CJ Kelley, ED Babu Breast 2006 Jun; 15(3): 313-8
• Function of indoleamine 2, 3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression (Original Research Article) SC Beutelspacher, R Pillai, MP Watson, PH Tan, J Tsang, MO McClure, AJ George, DF Larkin European Journal of Immunology 2006 Mar; 36(3): 690-700
• Effect of vectors on human endothelial cell signal transduction: implications for cardiovascular gene therapy (Original research article) PH Tan, SA Xue, M Manunta, SC Beutelspacher, H Fazekasova, AK Alam, MO McClure, AJ George Arteriosclerosis, Thrombosis, and Vascular Biology 2006 Mar; 26(3): 462-7
• Delivery of oligodeoxynucleotides into human saphenous veins: the adjunct effect of ultrasound and microbubbles (Original Research Article) T Kodama, PH Tan, I Offiah, T Partridge, T Cook, AJ George, MJ Blomley Ultrasound in Medicine and Biology 2005 Dec; 31(12): 1683-1691
• The evolving role of gene-based treatment in surgery (Review Article) PH Tan, CLH Chan, C Chan, AJ George British Journal of Surgery 2005 Dec; 92(12): 1466-1480
• Comparison of several viral vectors for gene therapy of corneal endothelial cells (Original Research Article) SC Beutelspacher, N Serbecic, PH Tan, MO McClure Ophthalmologe 2005 Dec; 102(12): 1168-74
• Creation of tolerogenic human dendritic cells via intracellular CTLA4- a novel strategy with potential in clinical immunosuppression (Plenary Article – Original Research Article) PH Tan, JB Yates, SA Xue, C Chan, WJ Jordan, JE Harper, MP Watson, R Dong, MA Ritter, RI Lechler, G Lombardi, AJ George Blood 2005 Nov; 106(9): 2936-2943
• Tolerant T cells display impaired trafficking (Original Research Article) V Mirenda, O Millington, RI Lechler, D Scott, MP Hernandez-Fuentes, J Read, PH Tan, AJ George, P Garside, FM Marelli-Berg European Journal of Immunology 2005 July, 33(7), 2146–2156
• Inhibition of NF[kappa]B and oxidative pathways in human dendritic cells by anti-oxidative vitamins generates regulatory T cells (Original Research Article) PH Tan, P Sagoo, C Chan, JB Yates, J Campbell, SC Beutelspacher, BM Foxwell, G Lombardi, AJ George, Journal of Immunology 2005 Jun; 174(12): 7633-44
• Comparison of HIV-1 and EIAV-based lentiviral vectors in corneal transduction (Original Research Article) SC Beutelspacher, N Ardjomand, PH Tan, GS Patton, DF Larkin, AJ George, MO McClure Experimental Eye Research 2005 Jun; 80(6): 787-94
• Modulation of human dendritic cell function following transduction with viral vectors: implications for gene therapy (Original Research Article) PH Tan, SC Beutelspacher, SA Xue, YH Wang, P Mitchell, JC McAlister, HJ Stauss, MA Ritter, DF Larkin, MO McClure, G Lombardi, AJ George Blood 2005 May; 105(10): 3824-32
• An efficient, non-viral alternative to viral vectors for transfection of human dendritic cells: a potential tool for clinical vaccination (Original Research Article) PH Tan, SC Beutelspacher, YH Wang, MO McClure, MA Ritter, G Lombardi, AJ George Molecular Therapy 2005 May; 11(5): 790-80
• Gene delivery by dendrimers operates via a cholesterol dependent pathway (Original Research Article) M Manunta, PH Tan, P Sagoo, K Kashefi, AJ George Nucleic Acids Research 2004 May; 32(9): 2730-9
• Low dose of ethanol modulate toxic effect of iron-overloading in the liver (Original Research Article) SC Beutelspacher, N Serbecic, PH Tan, M Mehrabi, P Nielson, Y Yamane Journal of Nutritional Science and Vitaminology 2004 Apr; 50(2): 78-86
• Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells (Original Research Article) PH Tan, C Chan, SA Xue, R Dong, B Anathesayanan, M Manunta, C Kerouedan, NJ Cheshire, JH Wolfe, DO Haskard, KM Taylor, AJ George Atherosclerosis 2004 Apr; 173(2): 171-83
• Modulation of co-stimulation by CD28 and CD154 alters the kinetics and cellular characteristics of corneal allograft rejection (Original Research Article) N Ardjomand, JC McAlister, NJ Rogers, PH Tan, AJ George, DF Larkin Investigative Ophthalmology Visual Science 2003 Sep; 44(9): 3899-905
• Antibody directed gene delivery to endothelium (Original Research Article) PH Tan, M Manunta, N Ardjomand, SA Xue, DFP Larkin, DO Haskard, KM Taylor, AJ George Journal of Gene Medicine 2003 Apr; 5(4): 311-23
• Transferrin receptor-mediated gene transfer to corneal endothelium (Original Research Article) PH Tan, WJ King, D Chen, HM Awad, M Mackett, RI Lechler, DF Larkin, AJ George Transplantation 2001 Feb; 71(4): 552-60
• Gene delivery to the corneal endothelium (Review Article) AJ George, CV Arancibia-Corcarno, HM Awad, RM Cromer, Z Fehevari, WJ King, M Hassan, T Huddle, C Lebosse, F Mirza, HB Oral, SA Rayner, PH Tan, E Tay, DF Larkin American Journal of Respiratory and Critical Care Medicine 2000 Oct; 162(4 Pt 2): S194-200
• Publication of letters & case reports:
• The Transplantation Society – New Key Opinion Leaders of Tomorrow 2006 (Meeting Report) PH Tan, K Giles, PL Tan Expert Opinion on Biological Therapy 2007 Jan; 7(1): 149-52
• World Transplant Congress. Boston, Massachusetts, USA, 22 – 27 July 2006 (Congress Report) PH Tan Expert Opinion on Biological Therapy 2006 Oct; 6(10): 1061-5
• 9th American Society of Gene Therapy Annual Meeting (Congressional Report) PH Tan Expert Opinion on Biological Therapy 2006 Aug; 6(8): 839-42
• American Transplant Congress 2005 (Congress Report) PH Tan Immunology News 2005 Aug; 12(3): 24-6
Mr Tan’s research interests embrace both basic and applied molecular biology in the context of cancer, transplantation and vascular biology, with an increasing emphasis on the translational research.
This includes obesity biology in areas of adiponectin and its signalling pathways; tumour immunology in the area of breast cancer; gene therapy vector development; induction of immunological tolerance by manipulating endothelial and dendritic cells; dendritic cell biology in the aspects of its co-stimulation, internalisation of antigen, antigenic presentation and signalling transduction; vascular biology; corneal transplantation studying corneal rejection model and corneal cellular biology and effect diabetes on antigenic presentation.