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Job title
Professor of medicine/honorary consultant; clinical service lead immunity and rare diseases
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Biography
Prof Lachmann trained in medicine at the University of Cambridge and at University College London, and specialises in amyloidosis and the autoinflammatory diseases.
She has published widely on the genetics and management of the systemic autoinflammatory diseases and characterisation and treatment of acquired and hereditary systemic amyloidosis.
GMC number
3585872
• Beck, D.B., Ferrada, M.A., Sikora, K.A., Ombrello, A.K., Collins, J.C., Pei, W., Baland, A N., Ross, D.L., Ospina Cardona, D., Wu, Z., Patel, B., Manthiram, .K,…Lachmann, H.J. , et al. Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease New England Journal of Medicine 2020; 383:2628-2638
• De Benedetti, F., Gattorno, M., Anton, J, Ben-Chetrit, E., Frenkel, J., Hoffman, H.M., Koné-Paut, I., Lachmann, H.J., Ozen, S., Simon, A., Zeft, A., Calvo Penades, I., et al. Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes. New England Journal of Medicine 2018; 378:1908-1919
• Ravichandran, R., Lachmann, H.J., Wechalekar, A.D. Epidemiologic and Survival Trends in Amyloidosis, 1987–2019 New England Journal of Medicine 2020 382:1567-1568
• Lachmann H.J. A New Era in the Treatment of Amyloidosis? New England Journal of Medicine 2013; 369:866-868
• Lachmann, H. J., Kone-Paut, I., Kuemmerle-Deschner, J. B., Leslie, K. S., Hachulla, E., Quartier, P., Gitton, X., Widmer, A., Patel, N., Hawkins, P. N. (2009). Use of canakinumab in the cryopyrin-associated periodic syndrome. New England Journal of Medicine 360(23), 2416-2425
• Dember, L.M., Hawkins, P.N.., Hazenberg, B.P.C., Gorevic, P.D., Merlini, G., Butrimiene, I., Livneh, A., Lesnyak, O., Puéchal, X., Lachmann, H.J., Obici, L., Balshaw, R., et al. Eprodisate for the Treatment of Renal Disease in AA Amyloidosis. New England Journal of Medicine 2007; 356:2349-2360
• Lachmann, H. J., Goodman, H. J. B., Gilbertson, J. A., Gallimore, J. R., Sabin, C. A., Gillmore, J. D., Hawkins, P. N. (2007). Natural history and outcome in systemic AA amyloidosis. New England Journal of Medicine 356(23), 2361-2371
• Lachmann, H. J., Booth, D. R., Booth, S. E., Bybee, A., Gilbertson, J. A., Gillmore, J. D., Pepys, M. B., Hawkins, P. N. (2002). Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. New England Journal of Medicine 346(23), 1786-1791
Prof Lachmann’s research interests are the genetics, characterisation and management of the systemic autoinflammatory diseases and of acquired and hereditary amyloidosis.